Research results were presented at the 79th Annual Meeting of the Japan Cancer Society
The Asai Germanium Research Institute presented research results at the 79th Annual Meeting of the Japan Cancer Society held at Hiroshima city on October 1~3, 2020.
Title: Organic germanium compound THGP differentiates macrophage strain RAW264.7 into M1 macrophages and induces antitumor activity
Presented by: Junya Azumi, Research Department
Result of the study
(1) Macrophages fed with Asaigermanium (Asai Germanium) (RAW264.7) were activated in M1 macrophages.
(2) The M1 macrophages in (1) have phagocytosis as the concentration of Asaigermanium (Asai Germanium) increases.
(3) When M1 macrophages (1) and mouse melanoma cells B16 4A5 (cancer cells) were co-cultured, it was confirmed that M1 macrophages phagocytosed mouse melanoma cells B16 4A5 (cancer cells).
(4) Mouse melanoma cells B16 4A5 (cancer cells) emit a signal called CD47 to avoid attack (phagocytosis) from macrophages, but it was confirmed that the recognition of CD47 was impaired in the M1 macrophage in (1).
(5) It was confirmed that the addition of Asaigermanium (Asai Germanium) to mouse melanoma cells B16 4A5 (cancer cells) also suppressed CD47 itself.
This study revealed a part of the mechanism of the “antitumor action” of Asaigermanium (Asai Germanium).
In the future, will continue to elucidate the mechanism of action in order to establish a useful use for health.