By Dr. Nakamura Atsushi M.D.
The work of doctors can be roughly divided into three types. Clinical, research, and education.
“Clinical” is a job for patients at the bedside or in the examination room. Usually, when I say doctors, I mean clinicians.
Performing various experiments with cells and animals is “research,” and new medical findings often come from this.
“Education” is the work of teaching medical knowledge to medical students, residents, nursing students, and sometimes students of other faculties.
Many doctors have no difficulty studying in the first place, probably because they have been studying as a child and have passed through the strict examination ratio.
Love to learn is a must-have for doctors. No, to be precise, there is nothing that can not be done with the ancient knowledge that I learned when I was a student, but in the age when the medical knowledge is no longer a monopoly of doctors due to the Internet, doctors who do not study Is more likely to be abandoned by patients. Even if they are abandoned by a patient, a working physician will be able to live without problems. However, practitioners who use old knowledge feel that a tough time has come.
Because of the constant need to update knowledge with the advancement of medicine, doctors study all their life ^^; Many
doctors like to teach people things because of their profession.
To teach is to learn. Teaching and learning seem to be opposites and are actually synonyms. These doctors are suitable for university hospitals.
I think that I’m originally suited for university hospitals. I like teaching, and yearn for a research field where I try and error silently.
The clinical setting is a serious one-on-one competition with the patient in front of the patient, which is of course rewarding. But even if I treat each patient individually and treat them like that, I can only do a limited amount of things. Rather than engaging in research and developing some groundbreaking methodologies, couldn’t it save a lot of people? For example, Hoffer is both a clinician and a researcher, discovering various benefits of niacin through clinical trials. How much of his work has saved the sick.
But even if they love teaching, they don’t want to be involved in spreading knowledge that can’t help patients, or even harmful useless knowledge, as is done in modern medical education.
I’m sorry if you want to do research but you can only do research that will contribute to the profits of pharmaceutical companies.
Regardless of education or research, I really want to help patients.
The other day, a research team by Takashi Nakamura of Asai Germanium Research Institute issued another paper. Yes, that’s what I want to do.
By submitting that new knowledge to the world, the world will become brighter. In the overwhelming flood of information, it’s just one of the little things, but the world just gets better.
It’s hard to get into research now, but at least I want to be that kind of information provider.
” Asaigermanium compound THGP inhibits melanin synthesis”
different in Asaigermanium compound 3- (trihydroxide germyl) propanoic acid (THGP) Biological activity. Previously we have reported that THGP forms a complex with the cis-diol structure. L-3,4-Phenylalanine dihydroxide (L-DOPA; precursor of melanin) contains a cis-diol structure in its own catechol skeleton, and excessive melanin production causes darkening and spots on the skin. For this reason, in the cosmetics industry, research on substances that suppress melanin production is being vigorously conducted.
In this study, we used mushroom tyrosinase (tyrosine degrading enzyme) and B164A5 melanoma cells to determine whether THGP suppresses melanin synthesis through complex formation with L-DOPA.
The ability of THGP to act on L-DOPA was analyzed by 1H-NMR to examine the effect of THGP (and kojic acid) on melanin synthesis.
In addition, the effects of THGP on cytotoxicity, tyrosinase activity, and gene expression were also investigated.
As a result, it was found that THGP acts on L-DOPA (a melanin precursor having a cis-diol structure).
Furthermore, it was found that THGP inhibits melanin synthesis, synergizes with kojic acid, and has no effect on tyrosinase activity or gene expression.
These results indicate that THGP is a useful substrate for inhibiting melanin synthesis, and that the effect of THGP is enhanced in combination with kojic acid.
In general medical school education, we learn the metabolic pathway of
phenylalanine → tyrosine → L-DOPA → dopamine → noradrenaline → adrenaline
If you are studying nutrition therapy, look at this cascade and recall Hoffer’s accomplishments. In other words, “Dopanochrome and adrenochrome (oxides of dopamine and adrenaline) are hallucinogenic, and hallucinations and delusions in schizophrenia are the effects of these substances. They also have cytostatic effects.
Therefore , people with schizophrenia rarely get cancer.Let’s take vitamin C to prevent oxidation of dopamine and adrenaline. “In such a context, we may see this metabolic pathway, but L-DOPA causes unun The story was rather cosmetic, and I wasn’t familiar with it, so this paper was fresh.
If the combined use of kojic acid and Asaigermanium can block the adverse effects of L-DOPA, would they both be effective not only for beautiful skin but also for schizophrenia?
If I’m a researcher, there are many hypotheses I want to test like this.